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| 晚期糖基化终末产物的特性及其研究现状分析 | |
| 引用本文： | 许良元,刘勇,张弓,翟玉峰,朱灵,吴路生.晚期糖基化终末产物的特性及其研究现状分析[J].光学与光电技术,2009,7(6):81-84. |
| 作者姓名： | 许良元 刘勇 张弓 翟玉峰 朱灵 吴路生 |
| 作者单位： | 1. 中国科学院安徽光学精密机械研究所,安徽合肥230031;安徽农业大学工学院,安徽合肥230036 2. 中国科学院安徽光学精密机械研究所,安徽合肥,230031 3. 加拿大温泥伯大学,马尼托巴 R3T6A5 |
| 基金项目： | 中国科学院知识创新工程青年人才领域专项前沿项目资助 |
| 摘 要： | 分析了晚期糖基化终末产物的生化特性和主要结构形式，介绍了目前检测晚期糖基化终末产物的主要方法和各自的优缺点，讨论了荧光光谱检测方法。用检测系统测试了晚期糖基化终末产物的激发光谱，同时采用370nm的单色光作为激发光源，分别对正常人和糖尿病患者的皮肤进行了荧光光谱检测，通过获得的发射荧光光谱分析可以发现两者在450nm附近的荧光存在明显的差异。结果表明该荧光光谱测量系统快速、无创、简单，可应用于对糖尿病、人体衰老、氧化应激等病情进行早期预测和诊断。 |
| 关 键 词： | 晚期糖基化终末产物 无创检测 方法 荧光光谱 |
Property of Advanced Glycation Endproducts |
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| XU Liang-yuan,LIU Yong,ZHANG Gong,ZHAI Yu-feng,ZHU Ling,WU Lu-sheng.Property of Advanced Glycation Endproducts[J].optics&optoelectronic technology,2009,7(6):81-84. | |
| Authors: | XU Liang-yuan LIU Yong ZHANG Gong ZHAI Yu-feng ZHU Ling WU Lu-sheng |
| Institution: | , ZHAI Yu-feng( 1Institute of Optics and Fine Mechanics,Chinese Academy of Sciences, Hefei 230031, China; 2 Engineering College, Anhui Agricultural University, Hefei 230036, China; 3 University of Winnipeg, Manitoba R3T6A5, Canada ) |
| Abstract: | The necessity to detect advanced glycation endproducts（AGE） and its biochemic property and main structure were analyzed in the paper. The main methods to detec AGE at present and their advantages and disadvantages were introduced. At the same time, the emission spectrum was detected on the skin of nondiabetic people and diabetes respectively. The result of the experiment indicates that there are differences distinctly about 450 nm between them. It proves the feasibility of the system. The process of the detection is very rapid and convenient. The patient can benefit from it to forecast and diagnose the state of illness such as diabetes,decrepitude,oxidative stress etc conveniently. |
| Keywords: | AGE noninvasive method fluorescence spectrum |
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