Deoxyribozyme-based ligase logic gates and their initial circuits |
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| Authors: | Stojanovic Milan N Semova Stanka Kolpashchikov Dmitry Macdonald Joanne Morgan Clint Stefanovic Darko |
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| Institution: | Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 West 168th Street, New York, NY 10032, USA. mns18@columbia.edu |
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| Abstract: | A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage. |
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