Synthesis of partially hydrogenated pyrazolo[3,4-b]quinolinones by condensation of 3-amino-5-methylpyrazole with aromatic aldehydes and dimedone |
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| Authors: | V V Lipson M G Shirobokova O V Shishkin S V Shishkina |
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| Institution: | (1) Danilevskii Institute of Endocrinic Pathology Problems, Academy of Medical Sciences of Ukraine, ul. Artema 10, Kharkiv, 61002, Ukraine;(2) State Scientific Enterprise Research and Technology Association “Institute of Single Crystals”, National Academy of Sciences of Ukraine, Ukraine |
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| Abstract: | Cyclocondensation of 3-amino-5-methylpyrazole with 2-arylmethylidene-5,5-dimethylcyclohexane-1,3-diones or 9-aryl-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-diones, as well as with synthetic precursors of the latter (para-substituted benzaldehydes and dimedone), in dimethylformamide or methanol gives the corresponding 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo3,4-b]quinolin-5-ones. The structure of 4-(4-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo3,4-b]quinolin-5-one was proved by the X-ray diffraction data. |
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