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Association between angiotensin-1 converting enzyme gene polymorphism and the metabolic syndrome in a Mexican population
Authors:Alvarez-Aguilar Cleto  Enríquez-Ramírez Maria Lucia  Figueroa-Nuñez Benigno  Gómez-García Anel  Rodríguez-Ayala Ernesto  Morán-Moguel Cristina  Farías-Rodríguez Victor Manuel  Mino-León Dolores  López-Meza Joel Edmundo
Affiliation:Unidad de Investigación en Epidemiología Clínica, Hospital General Regional No. 1, Morelia, Michoacán, México. calvareza@yahoo.com.mx
Abstract:Metabolic Syndrome (MS) is recognized as a cluster of cardiovascular risk factors. All components of MS have a genetic base. Genes of the renin angiotensin system are potential candidate genes for MS. We investigated whether angiotensin converting enzyme (ACE) gene polymorphism increases susceptibility to MS as an entity in a Mexican population. In a cross-sectional study, 514 individuals were studied including 245 patients with MS and 269 subjects without MS criteria. ACE gene polymorphism was detected using PCR. MS was defined according to The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) criteria, except that the raised fasting plasma glucose
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