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Kinetic-chromatographic determination of 4-methylaminoantipyrine in Pentalgin N and Pentalgin FS tablets |
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| Authors: | G B Golubitskii E V Budko E M Basova V M Ivanov |
| Institution: | (1) OAO Farmstandart-Leksredstva, Vtoraya Agregatnaya ul. 1a/18, Kursk, 305039, Russia;(2) Kursk State Medical University, ul. K. Marksa 3, Kursk, 305004, Russia;(3) Dubna International University of Nature, Society, and Human Being, Universitetskaya ul. 19, Dubna, Moscow oblast, 141980, Russia;(4) Department of Chemistry, Moscow State University, Vorob’evy gory, Moscow, 119992, Russia |
| Abstract: | 4-Methylaminoantipyrine (4-MAAP) is the main product of analgin decomposition in aqueous-organic solutions used in the analysis of Pentalgin N and Pentalgin FS tablets. The determination of 4-MAAP in tablets is complicated by the fast decomposition of analgin in the course of sample dissolution. The use of nonaqueous solvents in subsequent HPLC analysis is unreasonable, because the shapes of analyte peaks are deteriorated and the decomposition of analgin is not prevented. A procedure for the kinetic-chromatographic determination of both 4-MAAP in tablets and its amount at the moment of sample dissolution is proposed. |
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