| 红葱中的新化学成分 |
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| 引用本文： | 邱峰,徐金钟,段文娟,曲戈霞,王乃利,姚新生.红葱中的新化学成分[J].高等学校化学学报,2005,26(11):2057-2060. |
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| 作者姓名： | 邱峰 徐金钟 段文娟 曲戈霞 王乃利 姚新生 |
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| 作者单位： | 沈阳药科大学天然药物化学教研室, 沈阳110016 |
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| 摘 要： | 通过正相和反相硅胶柱色以及高效液相色谱,从红葱60%乙醇提取物中分离得到3个新化合物,利用物理化学和光谱学方法鉴定了其结构,分别为9,9'-二羟基-8,8'-二甲氧基-1,1'-二甲基-1H,1H-'4,4']双萘并(2,3-c)呋喃]-3,3'-二酮(1),6,8-二羟基-3,4-二甲氧基-1-甲基-蒽醌-2-羧酸甲酯(2),2-乙酰基-3,6,8-三羟基-1-甲基蒽醌(3).这3个化合物均能不同程度地诱导稻瘟霉菌丝变形,其最小变形质量浓度(Mini-mummorphologicaldeformationmassconcentration,MMDC)分别为145.8,50.2和124.8μg/mL.利用MTT法测定了化合物抑制人类红白血细胞株K562细胞生长的活性,化合物2的IC50为49.1μg/mL.
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| 关 键 词： | 红葱 生物活性 稻瘟霉菌 人类红白血细胞株 |
| 文章编号： | 0251-0790（2005）11-2057-04 |
| 收稿时间： | 10 20 2004 12:00AM |
| 修稿时间： | 2004-10-20 |
New Constituents from Eleutherine americana |
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| QIU Feng,XU Jin-Zhong,DUAN Wen-Juan,QU Ge-Xia,WANG Nai-Li,YAO Xin-Sheng.New Constituents from Eleutherine americana[J].Chemical Research In Chinese Universities,2005,26(11):2057-2060. |
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| Authors: | QIU Feng XU Jin-Zhong DUAN Wen-Juan QU Ge-Xia WANG Nai-Li YAO Xin-Sheng |
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| Institution: | Department of Natural Products Chemistry,Shenyang Pharmaceutical University,Shenyang 110016,China |
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| Abstract: | Three new constituents were isolated from Eleutherine americana Merr.et K.Heyne(Hong-cong)by means of silica gel,ODS column chromatography and high performance liquid chromatography(HPLC).They were identified as 9,9'-dihydroxy-8,8'- dimethoxy-1,1'-methyl-1H,1H'-\bi\funanyl]-3,3'-dione(1),6,8-dihydroxy-3,4-dimethoxy-1-methyl-anthraquinone-2-carboxylic acid methyl ester(2),2-acetyl-3,6,8-trihydroxy-1-methylanthraquinone(3) by physico-chemical propeties and spectral data,respectively.All three compounds showed weak activities against the growth of Pyricularia oryzae.The MMDC(Minimum morphological deformation mass concentration) was 145.8,50.2,124.8 μg/mL.Additionally,compound 2 also inhibited the proliferation of K562(human erythroleukemia) with IC50 value of 49.1 μg/mL. |
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| Keywords: | Eleutherine americana Bioactivity Pyricularia oryzae Human erythroleukemia |
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