Heterocycles [<Emphasis Type="Italic">h</Emphasis>]-fused to 4-oxoquinoline-3-carboxylic acid. Part VII: synthesis of some 6-oxoimidazo[4,5-<Emphasis Type="Italic">h</Emphasis>]quinoline-7-carboxylic acids and esters |
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| Authors: | Maram R Al-Dweik Jalal A Zahra Monther A Khanfar Mustafa M El-Abadelah Klaus-Peter Zeller Wolfgang Voelter |
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| Institution: | 1.Chemistry Department, Faculty of Science,University of Jordan,Amman,Jordan;2.Institut für Organische Chemie,Universit?t Tübingen,Tübingen,Germany;3.Interfakult?res Institut für Biochemie,Universit?t Tübingen,Tübingen,Germany |
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| Abstract: | Abstract A series of ethyl 2-(substituted)-9-cyclopropyl-4-fluoro-6-oxo-1H-imidazo4,5-h]quinoline-7-carboxylates has been prepared from ethyl 7,8-diamino-1,4-dihydroquinoline-3-carboxylate via thermally induced
reactions with model alkanoic acids or via microwave-assisted cyclocondensation with some arene carboxaldehydes. Acid-catalysed
hydrolysis of the resulting ester derivatives furnished the corresponding imidazoquinoline-7-carboxylic acids. The structures
of these new acid and ester derivatives are based on microanalytical and spectral (IR, MS, and NMR) data.
Graphical abstract
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| Keywords: | 7 8-Diaminofluoroquinolone Alkanoic acids Arene carboxaldehydes Cyclocondensation Microwave irradiation |
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