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Bioactive pregnane-type steroids from the soft coral Scleronephthya gracillimum |
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| Authors: | Hui-Yu Fang Chih-Chuang Liaw Chih-Hua ChaoZhi-Hong Wen Yang-Chang WuChi-Hsin Hsu Chang-Feng DaiJyh-Horng Sheu |
| Institution: | a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804,Taiwan b Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan c Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan d Asia Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
| Abstract: | Nine new steroids, sclerosteroids A-I (1, 5, 6, 8-13), along with 18 known metabolites (2-4, 7, 14-27), were isolated from the soft coral Scleronephthya gracillimum. These structures were elucidated on the basis of detailed spectroscopic analysis. The absolute configurations of sugar moieties in steroidal glycosides 10-13 were determined by HPLC analysis of the o-tolylthiocarbamate derivatives of the liberated sugars from hydrolysis of these steroidal giycosides. Cytotoxic and anti-inflammatory activities of these compounds were measured in vitro. |
| Keywords: | Scleronephthya gracillimum Sclerosteroids O-Tolylthiocarbamate Cytotoxic activity Anti-inflammatory activity |
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