Stereoselective synthesis of the phorboxazole A macrolide by ring-closing metathesis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Stereoselective synthesis of the phorboxazole A macrolide by ring-closing metathesis

Authors:	Wang Bo Forsyth Craig J

Affiliation:	Department of Chemistry, Institute of Technology, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, USA.

Abstract:	[Structure: see text] Described is a regio- and stereoselective ring-closing metathesis (RCM) to form the C2-C3 alkene of the macrolide-containing domain of phorboxazole A. This work demonstrates a dramatic effect of reaction solvent on RCM product (E/Z)-selectivity. This process offers an alternative assembly of the macrolide-containing domain of phorboxazole A, one of the most potent anticancer agents known.

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