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| 肽脱甲酰化酶抑制剂的合成及其抑菌活性 | |
| 引用本文： | 孟丽娟,汤立达,贾炯,徐为人,张大同,张士俊,王平保,冯勇,任戎,王建武.肽脱甲酰化酶抑制剂的合成及其抑菌活性[J].合成化学,2006,14(3):229-233,243. |
| 作者姓名： | 孟丽娟 汤立达 贾炯 徐为人 张大同 张士俊 王平保 冯勇 任戎 王建武 |
| 作者单位： | 1. 山东大学,化学与化工学院,山东,济南,250100 2. 山东大学,化学与化工学院,山东,济南,250100;天津药物研究院,天津,300193 3. 天津药物研究院,天津,300193 |
| 基金项目： | 国家重点基础研究发展计划(973计划) |
| 摘 要： | 通过对肽脱甲酰化酶抑制剂构效关系的研究,以放线酰胺素为先导化合物,设计并合成了一系列异噁唑类化合物。其结构经1H NMR,IR,MS和元素分析表征。生物活性实验表明,该类化合物对标准肺炎克雷白球菌有显著的抑菌活性。 |
| 关 键 词： | 肽脱甲酰化酶 抑制剂 合成 抑菌活性 |
| 文章编号： | 1005-1511（2006）03-0229-05 |
| 收稿时间： | 2005-12-26 |
| 修稿时间： | 2005-12-26 |
Synthesis of Peptide Deformylase Inhibitor and Their Bacteriostasis Activity |
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| MENG Li-juan,TANG Li-da,JIA Jiong,XU Wei-ren,ZHANG Da-tong,ZHANG Shi-jun,WANG Ping-bao,FENG Yong,REN Rong,WANG Jian-wu.Synthesis of Peptide Deformylase Inhibitor and Their Bacteriostasis Activity[J].Chinese Journal of Synthetic Chemistry,2006,14(3):229-233,243. | |
| Authors: | MENG Li-juan TANG Li-da JIA Jiong XU Wei-ren ZHANG Da-tong ZHANG Shi-jun WANG Ping-bao FENG Yong REN Rong WANG Jian-wu |
| Institution: | 1, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China; 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
| Abstract: | According to the structure-activity relationship of peptide deformylase inhibitors,a series of hydroxamic acid derivatives containing isoxazole were designed and synthesized based on the structure of actinonin.The structures of compounds were characterized by ~1H NMR,IR,MS and elemental analysis.The preliminary biological test showed that some compounds exhibited bacteriostasis activities. |
| Keywords: | peptide deformylase inhibitor synthesis bacteriostasis activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |