胆甾-4α-甲基-8-烯-3β，7α-二醇二乙酸酯的结构与性质研究

Lophenol, cholest-4α-methyl-7-en-3β-ol (1), obtained from Dracaena cochinchinensis (Lour.) S. C. Chen, was structurally modified. It was acetylated to protect 3β-hydroxyl group, and then oxidised by selenium dioxide in acetic acid to give cholest-4a-methyl-8-en-3β, Ta-diol diacetate (3). This compound 3 is unstable in chloroform solution or when heated and easily converted to a diene compound, cholest-4a-methyl-7,14-dien-3β-ol acetate (4). The structures of 3 and 4 were elucidated by means of IR, ^1H NMR, ^13C NMR and MS, and the absolute configuration of 3 was established by X-ray crystallography. The property of 3 was also discussed in this paper. Both 3 and 4 are new compounds and were reported for the first time.

Structure and Properties of Cholest‐4α‐methyl‐8‐en‐3β,7α‐diol Diacetate

Lophenol, cholest‐4α‐methyl‐7‐en‐3β‐ol ( 1 ), obtained from Dracaena cochinchinensis (Lour.) S. C. Chen, was structurally modified. It was acetylated to protect 3β‐hydroxyl group, and then oxidised by selenium dioxide in ace‐tic acid to give cholest‐4α‐methyl‐8‐en‐3β,7α‐diol diacetate ( 3 ). This compound 3 is unstable in chloroform solution or when heated and easily converted to a diene compound, cholest‐4α‐methyl‐7,14‐dien‐3β‐ol acetate ( 4 ). The structures of 3 and 4 were elucidated by means of IR, ¹H NMR, ¹³C NMR and MS, and the absolute configuration of 3 was established by X‐ray crystallography. The property of 3 was also discussed in this paper. Both 3 and 4 are new compounds and were reported for the first time.