Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors |
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Authors: | Alain A Camilleri Raffaella Willmann Gayathri Sadasivam Shuo Lin Markus A Rüegg Matthias Gesemann Christian Fuhrer |
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Institution: | (1) Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland;(2) Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland |
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Abstract: | Background Development of neural networks requires that synapses are formed, eliminated and stabilized. At the neuromuscular junction
(NMJ), agrin/MuSK signaling, by triggering downstream pathways, causes clustering and phosphorylation of postsynaptic acetylcholine
receptors (AChRs). Postnatally, AChR aggregates are stabilized by molecular pathways that are poorly characterized. Gain or
loss of function of Src-family kinases (SFKs) disassembles AChR clusters at adult NMJs in vivo, whereas AChR aggregates disperse rapidly upon withdrawal of agrin from cultured src
-/-;fyn
-/- myotubes. This suggests that a balance between protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) such
as those of the Src-family may be essential in stabilizing clusters of AChRs. |
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Keywords: | |
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