| 邻二氮菲分光光度法测定盐酸氯丙嗪 |
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| 引用本文： | 张一敏,刘珂珂,叶存玲,王治科. 邻二氮菲分光光度法测定盐酸氯丙嗪[J]. 分析试验室, 2012, 31(1): 39-41. DOI: 10.3969/j.issn.1000-0720.2012.01.009 |
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| 作者姓名： | 张一敏 刘珂珂 叶存玲 王治科 |
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| 作者单位： | 1.河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡,453007;2.河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡,453007;3.河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡,453007;4.河南师范大学化学与环境科学学院河南省环境污染控制重点实验室,新乡,453007 |
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| 基金项目： | 国家自然科学基金项目(20977025)资助 |
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| 摘 要： | 在HAc-NaAc缓冲介质中,盐酸氯丙嗪(CPZ)能定量使Fe(Ⅲ)还原为Fe(Ⅱ),还原生成的Fe(Ⅱ)与邻二氮菲反应生成稳定的红色络合物,并且在一定范围内,CPZ的浓度和生成的红色络合物的吸光度呈良好的线性关系.据此,提出邻二氮菲-Fe(Ⅲ)体系测定盐酸氯丙嗪的新方法.在优化的实验条件下,盐酸氯丙嗪的质量浓度在0.040～15.00mg/L范围内与吸光度呈现良好的线性关系,线性相关系数R=0.9995,摩尔吸光系数ε=2.8×104L·mol-1·cm-1,检出限为0.020mg/L.11次重复测定的相对标准偏差小于2.9％.该方法用于药物中盐酸氯丙嗪的测定,结果满意.
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| 关 键 词： | 盐酸氯丙嗪 Fe(Ⅲ) 邻二氮菲 分光光度法 |
Spectrophotometric determination of chlorpromazine hydrochloride by 1,10-phenanthroline |
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| ZHANG Yi-min,LIU Ke-ke,YE Cun-ling and WANG Zhi-ke. Spectrophotometric determination of chlorpromazine hydrochloride by 1,10-phenanthroline[J]. Chinese Journal of Analysis Laboratory, 2012, 31(1): 39-41. DOI: 10.3969/j.issn.1000-0720.2012.01.009 |
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| Authors: | ZHANG Yi-min LIU Ke-ke YE Cun-ling WANG Zhi-ke |
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| Affiliation: | ZHANG Yi-min,LIU Ke-ke,YE Cun-ling* and WANG Zhi-ke(School of Chemistry and Environmental Science,Henan Key Laboratory for Environmental Pollution Control,Henan Normal University,Xinxiang 453007) |
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| Abstract: | A new spectrophotometric method for the determination of chlorpromazine hydrochloride in pharmaceuticals was proposed.The developed method was based on the redox reaction of chlorpromazine hydrochloride and Fe(Ⅲ) in the HAc-NaAc buffer solutions.The reaction product Fe(Ⅱ) can form a red colored product with 1,10-phenanthroline.Under the optimum conditions,the absorbance was proportional to the concentration of chlorpromazine hydrochloride in the range of 0.040～15.00 mg/L and the detection limit was 0.02 mg/L.The molar absorptivity was 2.8×104 L·mol-1·cm-1.The relative standard deviation of 11 replicate measurements was less than 2.9%.The proposed method has been applied to the determination of chlorpromazine hydrochloride in pharmaceuticals. |
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| Keywords: | Chlorpromazine hydrochloride Fe(Ⅲ) 1,10-Phenanthroline Spectrophotometry |
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