Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion |
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| Authors: | Marijke WA de Backer Maike AD Brans Mieneke CM Luijendijk Keith M Garner Dianne MA van den Heuvel R Jeroen Pasterkamp Roger AH Adan |
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| Affiliation: | (1) Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Utrecht University Medical Centre Utrecht, Utrecht, The Netherlands |
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| Abstract: | ![]()
Background Multiple neuropeptides, sometimes with opposing functions, can be produced from one precursor gene. To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish local secretion. |
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