SRXRF study of trace elements in hippocampus of pup rats after prenatal and postnatal exposure to low-level mercury |
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| Authors: | F Zhang W Y Feng J W Shi M Wang Y Y Huang W He Z F Chai |
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| Institution: | (1) Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China;(2) Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing, 100049, P.R. China;(3) Lab of Synchrotron Radiation, Institute of High Energy Physics, CAS, Beijing, 100049, P.R. China;(4) Institute of Nuclear Technology, Shenzhen University, Shenzhen, 518060, P.R. China |
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| Abstract: | The damage in the pup rat brain with low-level mercury exposure, and the concentration variation of trace elements in the
rat hippocampus was determined by synchrotron radiation X-ray fluorescence technique (SRXRF). Meanwhile, the levels and activities
of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA)
in the hippocampus were also measured. The results showed that the low dose of inorganic mercury prenatal and postnatal exposure
could lead to the significant increase of both copper and zinc contents and remarkable decrease of iron content in pup rat
brain. Compared to the control group, the activities of antioxidant enzymes such as GSH-Px, SOD, the contents of GSH and MDA
in the pup rat hippocampus of mercury-exposed group fell down obviously. |
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