| 水溶性锌卟啉配合物的合成、表征及其与CTDNA的作用 |
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| 引用本文： | 康敬万,吴海霞,卢小泉,苏碧泉,卓琳.水溶性锌卟啉配合物的合成、表征及其与CTDNA的作用[J].高等学校化学学报,2005,26(6):997-1001. |
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| 作者姓名： | 康敬万 吴海霞 卢小泉 苏碧泉 卓琳 |
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| 作者单位： | 西北师范大学化学化工学院, 兰州730070 |
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| 基金项目： | 国家自然科学基金;西北师范大学校科研和教改项目 |
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| 摘 要： | 合成了5,10,15,20-四4-(3'-丙氧基吡啶溴化盐)苯基]卟啉(TPPBr)及其锌卟啉配合物TPPBr(Zn),用红外光谱、核磁共振和紫外光谱进行了表征.利用紫外-可见光谱、荧光光谱、圆二色谱和黏度实验研究了TPPBr(Zn)与小牛胸腺DNA(CTDNA)的相互作用,并计算了TPPBr(Zn)与CTDNA作用的表观键合常数为2.64×105L/mol.进而证明了TPPBr(Zn)与CTDNA以外部自堆积和静电结合的混合模式作用.
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| 关 键 词： | 水溶性锌卟啉 DNA 自堆积和静电结合模式 |
| 文章编号： | 0251-0790(2005)06-0997-05 |
| 收稿时间： | 2004-08-16 |
Synthesis and Characterization of Water-soluble Zinc Porphyrin Complex and Its Interaction with CT DNA |
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| KANG Jing-wan,Wu Hai-xia,LU Xiao-quan,SU Bi-Quan,ZHOU Lin.Synthesis and Characterization of Water-soluble Zinc Porphyrin Complex and Its Interaction with CT DNA[J].Chemical Research In Chinese Universities,2005,26(6):997-1001. |
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| Authors: | KANG Jing-wan Wu Hai-xia LU Xiao-quan SU Bi-Quan ZHOU Lin |
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| Institution: | Department of Chemistry, Northwest Normal University, Lanzhou 730070, China |
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| Abstract: | A porphyrin 5,10,15,20-tetrakisporphyrin and its Zn complex(TPPBr(Zn)) were synthesized and characterized. The interaction of TPPBr(Zn) with CT DNA was studied by UV-Vis spectroscopy, fluorescence spectra, circular dichroic spectrum and viscosity measurements. The constant of TPPBr(Zn) binding to CT DNA is 2.64×105 L/mol. The results suggest that the porphyrin complex can bind to DNA by self-stacked outside binding and static binding. |
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| Keywords: | DNA |
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