An improved optimization procedure for the selection of mixed mobile phases in reversed phase liquid chromatography |
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| Authors: | A. C. J. H. Drouen H. A. H. Billiet P. J. Schoenmakers L. de Galan |
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| Affiliation: | (1) Laboratorium voor Analytische Scheikunde, Technische Hogeschool Delft, Jaffalaan 9, 2628 BX Delft, The Netherlands |
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| Abstract: | ![]()
Summary The stepwise procedure described previously [1] for the selection of optimal mobile phase compositions in reversed phase liquid chromatography (RPLC) is improved in two ways. The optimization criterion is modified to account for variations in analysis time. The iterative approach to the optimal solvent composition makes a more efficient use of previous data. An example illustrates the resulting gain in speed and accuracy.Presented at the  14th International Symposium on Chromatography London, September, 1982 |
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| Keywords: | RP-HPLC Optimization Complex mobile phases Iso-eluotropic mixtures |
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