| Synthesis,Crystal Structure and Antifungal Activity of N-（Pyridine-2-methyl）-2-（4- chlorophenyl）-3-methylbutanamide |
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| 作者姓名： | CHEN Long XUE Si-Jia FANG Zhi-Kun YIN An-Qin XU Yang |
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| 作者单位： | Department of Chemistry, College of Life and Environmental Science,Shanghai Normal University, Shanghai 200234, China |
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| 基金项目： | 国家自然科学基金，Shanghai Leading Academic Discipline |
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| 摘 要： | A novel compound N-（pyridine-2-methyl）-2-（4-chlorophenyl）-3-methylbutanamide, a racemic compound, has been synthesized with 2-（4-chlorophenyl）-3-methylbutyric acid and pyridin- 2-methylanamine as the raw materials, and its crystal structure （C17H19C1N2O, Mr = 302.79） was determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic, space group P21/n with a = 9.624（9）, b = 23.14（2）, c = 15.626（15）A, β = 106.199（14）°, V = 3342（5） A^3, Z = 8, Dc = 1.204 g/cm^3,μ = 0.23 mm^-1, F（000） = 1280, S = 1.032, R = 0.0681 and wR = 0.1508 for 6513 unique reflections （Rint = 0.0421） with 3375 observed ones. In the crystal structure, there are some intermolecular hydrogen bonds which stabilize the crystal structure. The preliminary bioassay shows that the title compound exhibits good antifungal activity against Botrytis cinerea, Gibberella zeae, Dothiorella gregaria and Colletotrichum gossypii.
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| 关 键 词： | 晶体结构 氢键 化学结构 化合物 真菌活性 |
Synthesis, Crystal Structure and Antifungal Activity of N-(Pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide |
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| CHEN Long XUE Si-Jia FANG Zhi-Kun YIN An-Qin XU Yang.Synthesis, Crystal Structure and Antifungal Activity of N-(Pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide[J].Chinese Journal of Structural Chemistry,2009,28(8):990-994. |
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| Authors: | CHEN Long XUE Si-Jia FANG Zhi-Kun YIN An-Qin XU Yang |
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| Institution: | Department of Chemistry, College of Life and Environmental Science,Shanghai Normal University, Shanghai 200234, China |
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| Abstract: | A novel compound N-(pyridine-2-methyl)-2-(4-chlorophenyl)-3-methylbutanamide, a racemic compound, has been synthesized with 2-(4-chlorophenyl)-3-methylbutyric acid and pyridin-2-methylanamine as the raw materials, and its crystal structure (C17H19C1N2O, Mr=302.79) was determined by single-crystal X-ray diffraction analysis. The crystal belongs to monoclinic, space group P21/n with a=9.624(9), b=23.14(2), c=15.626(15)A, β=106.199(14)°, V=3342(5)A3, Z=8, Dc=1.204 g/cm3,μ=0.23 mm-1, F(000)=1280, S=1.032, R=0.0681 and wR=0.1508 for 6513 unique reflections (Rint=0.0421) with 3375 observed ones. In the crystal structure, there are some intermolecular hydrogen bonds which stabilize the crystal structure. The preliminary bioassay shows that the title compound exhibits good antifungal activity against Botrytis cinerea, Gibberella zeae, DothioreUa gregaria and Colletotrichum gossypii. |
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| Keywords: | 2-(4-chlorophenyl)-3-methylbutyric acid crystal structure synthesis antifungal activity |
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