Evaluation of lipid peroxidation inhibition and free radical scavenging abilities of 5,6,7-trimethoxy dihydroflavonols |
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| Authors: | Ke Xin Huanga Yu Bing Fengb Wei Yao Lei Xiang Yangb Feng Wangb Hai Bo Li Su Zengb Jing Xu Gongb Ming Hui Hub Yu Zhao Xiu Mei Wua Xiao Kun Li(a Jia Qua a Key Laboratory of Southern Zhejiang TCM R&D Pharmacy School of Wenzhou Medical College Wenzhou China b College of Pharmaceutical Sciences Zhejiang University Hangzhou China c Zhejiang Chemical Industry Research Institute Zhejiang Chem-Tech Group Co. Ltd. Hangzhou China d College of Pharmacy Pharmaceu... |
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| Affiliation: | a Key Laboratory of Southern Zhejiang TCM R&D, Pharmacy School of Wenzhou Medical College, Wenzhou 325035, China;b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;c Zhejiang Chemical Industry Research Institute, Zhejiang Chem-Tech Group Co., Ltd., Hangzhou 310023, China;d College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, FL 32307, USA |
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| Abstract: | Four naturally rare 5,6,7-trimethoxy-2,3-cis-dihydroflavonols (3–6) and two 5,6,7-trimethoxy-2,3-trans-dihydroflavonols (7–8) were designed and synthesized. Their antioxidative properties were evaluated by way of examining their scavenging capacities towards DPPH and O2 − free radicals, as well as by measuring their inhibitory ability against LPO. Both the 2,3-trans and the 2,3-cis conformers exhibited certain quenching abilities to DPPH and O2− radicals, while most of the synthetic dihydroflavonols demonstrated remarkable inhibition to LPO. |
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| Keywords: | 5,6,7-Trimethoxy-2,3-dihydroflavonols cis-Dihydroflavonols Antioxidant Lipid peroxidation Free radical scavenger |
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