One-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed three-component cascade annulation of amines,alkyne esters and terminal alkynes |
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| Authors: | Yunlan Li Qiurui Zhang Xuefeng Xu Xu Zhang Yurong Yang Wei Yi |
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| Affiliation: | 1. School of Chemistry and Pharmacony Engineering, Nanyang Normal University, Nanyang 473061, China;2. Key Laboratory of Molecular Target and Clinical Pharmacology & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China |
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| Abstract: | Described herein is a new and general method for one-pot synthesis of 2,4-disubstituted quinolines via silver-catalyzed [3?+?1?+?2] annulation of simple amines, alkyne esters and terminal alkynes. The versatile transformation might initiate with the facile formation of the enamine species with the feature of good to excellent yields, exclusive regioselectivity, and excellent substrate/functional group tolerance. |
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| Keywords: | MDTQLKTUBJSEPG-UHFFFAOYSA-N MQWCCBQFBPIBPR-UHFFFAOYSA-N AgOTf catalyst Amines Alkyne esters Terminal alkynes 2,4-Disubstituted quinolines |
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