Approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines |
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| Authors: | Andrii I. Subota Oleksiy S. Artamonov Alina Gorlova Dmitriy M. Volochnyuk Oleksandr O. Grygorenko |
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| Affiliation: | 1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv 02660, Ukraine;2. National Taras Shevchenko University of Kyiv, Volodymyrska Street, 64, Kyiv 01601, Ukraine |
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| Abstract: | ![]()
An approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines via the cyclization of 1-(2-(3-azidopropyl)pyridin-3-yl)alkanones under Staudinger–aza-Wittig reaction conditions is described. The overall reaction sequence includes eight steps and allows for the preparation of gram quantities of the title products. In some cases, the formation of 5,7,8,9-tetrahydrooxepino[4,3-b]pyridine derivatives was observed. |
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| Keywords: | Nitrogen heterocycles Fused azepanes Pyridine Aza-Wittig reaction Lead-oriented synthesis |
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