Construction of multifunctional heterocycles bearing aza-quaternary carbons by titanocene-catalyzed umpolung reactions |
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| Authors: | Jiang-Tao Cheng Xiao Zheng Pei-Qiang Huang |
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| Affiliation: | Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, PR China |
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| Abstract: | The combined application of Grignard/Reformatsky addition and the titanocene-catalyzed umpolung α-amino carbon-carbon bond formations provided a flexible and versatile protocol for preparation of multifunctional pyrrolidinones/piperidinones/N-Boc-piperidines bearing aza-quaternary carbons (AQC) from cyclic imides and analogues. Based on these multifunctional single-ring motifs, several advanced AQC-bearing heterocycles, such as AQC-possessing indolizidines and 1-azaspirocycles, have been constructed efficiently. |
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| Keywords: | Titanocene-catalyzed Umpolung Multifunctional Heterocycle Aza-quaternary carbon |
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