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Recent advances in indoline synthesis |
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| Authors: | Thiago S. Silva Manoel T. Rodrigues Hugo Santos Lucas A. Zeoly Wanda P. Almeida Rosimeire C. Barcelos Ralph C. Gomes Fábio S. Fernandes Fernando Coelho |
| Affiliation: | 1. Laboratory of Synthesis of Natural Products and Drugs, Institute of Chemistry, University of Campinas, PO Box 6154, 13083-970, Campinas, SP, Brazil;2. Faculty of Pharmaceutical Sciences, University of Campinas, Rua Cândido Portinari, 200, 13083-971, Campinas, SP, Brazil;3. Instituto Federal de Ciência, Tecnologia e Educação de Minas Gerais, Belo Horizonte, MG, Brazil |
| Abstract: | Indoline is an important structural motif present in several biologically active compounds from both natural and synthetic origins. The occurrence of this heterocyclic unity in these compounds is closely related to the biological activities they exhibit. This fact stimulated efforts that have been made worldwide to develop new synthetic approaches to prepare indolines. In this paper we reviewed critically the methods for indoline synthesis developed in the last years (from 2010 to 2018). |
| Keywords: | Indolines Heterocycles Transition metals Organocatalysis Cyclizations |
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