Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities |
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| Authors: | Zhan-Xing Hu Hong-Yu Tang Jie Guo Haji Aker Aisa Yu Zhang Xiao-Jiang Hao |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China;3. University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China;4. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China;5. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China;6. School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China |
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| Abstract: | Stemtuberlines A (1) and B (2), two new alkaloids with a unique tricyclic pyrrolo [3,2,1-jk]benzazepine-12-one nucleus, three new croomine-type alkaloids, stemtuberlines C-E (3–5), together with seven known ones were isolated from the roots of Stemona tuberosa. The structures of the new alkaloids were elucidated based on a comprehensive spectroscopic data analysis. The absolute configurations of 1 and 2 were determined by quantum ECD calculations. The anti-tobacco mosaic virus activity of the Stemona alkaloids was firstly evaluated and compound 11 exhibited significant anti-tobacco mosaic virus activity with the curative inhibition rate of 84.6% at concentration of 50?μg/mL. |
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| Keywords: | Stemona tuberosa Stemona alkaloids Stemtuberline A Anti-TMV |
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