| 有机锗对铅所致小鼠学习记忆障碍的拮抗作用 |
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| 引用本文： | 韩春姬 李连姬. 有机锗对铅所致小鼠学习记忆障碍的拮抗作用[J]. 广东微量元素科学, 1999, 6(3): 28-29 |
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| 作者姓名： | 韩春姬 李连姬 |
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| 作者单位： | 延边大学医学院卫生学教研室!吉林省延吉市，133000，延边大学医学院卫生学教研室!吉林省延吉市，133000，延边大学医学院卫生学教研室!吉林省延吉市，133000，延边大学医学院卫生学教研室!吉林省延吉市，133000，延边大学医学院卫生学教研室!吉林省延吉市，133000 |
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| 摘 要： | 用避暗法和水迷宫法研究了对铅所致的小鼠记忆障碍的影响。ＩＣＲ系小鼠隔日腹腔注射羧乙基锗 半氧化物（Ｇｅ－１３２，２５ｍｇ／ｋｇ），和／或醋酸铅（１５ｍｇ／ｋｇ）２８ｄ。结果表明暴露于铅２０ｄ后小鼠学习记忆能力受障碍，同时给予Ｇｅ－１３２能明显拮抗铅的毒性作用。试验提示Ｇｅ－１３２能拮抗所致的神经行为为功能的破坏作用。
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| 关 键 词： | 铅中毒 锗 有机锗 学习记忆障碍 拮抗作用 |
Effect of Germanium on Learning and Memory Disturbance Caused by Lead in Mice |
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| Han Chunji, Li Lianji, Qiu Delai et al. Effect of Germanium on Learning and Memory Disturbance Caused by Lead in Mice[J]. Trace Elements Science, 1999, 6(3): 28-29 |
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| Authors: | Han Chunji Li Lianji Qiu Delai et al |
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| Abstract: | By using step through test and water maze test, the effects of germanium on ICR mouse leam-ing and memory disturbance caused hy lead were studied by administering i. p. carboxyethyl - germaniumsesquiokide i. p. (Ge - 132, 25 mg/kg ) and/or lead acetate(PbAc2, 15 mg/kg ) for 28 d, one timeevery two days. The results showed that after exposure to lead for 20 d, the leaming and memoty distur-bance caused by the injection of PbAc2 was significantly antagonized by Ge - 132(P < 0.01 ). This sug-gested that Ge - 132 might play a protectivte role in neurobehavioral function damage induced by lead. |
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| Keywords: | Lead poisoning Germanium Learning and memory disturbance |
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