Facile N-1 protection of cyclam, cyclen and 1,4,7-triazacyclononane |
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| Authors: | Wen Yang Christen M. GiandomenicoMichael Sartori Dennis A. Moore |
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| Affiliation: | AnorMED, Inc. 200 20353 64th Ave, Langley, British Columbia, Canada V2Y 1N5 |
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| Abstract: | ![]()
An exceptionally high yielding method for the tri-protection of cyclam and cyclen using ethyl trifluoroacetate is described. The selective reaction also applies to the di-protection of 1,4,7-triazacyclononane. The application of this method in the synthesis of AMD3100, a clinical candidate for stem cell mobilization is presented. |
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