A facile synthesis of 4- and 6-chloromethyl-1H-indole-2-carboxylates: replacement of a sulfonic acid functionality by chlorine |
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| Authors: | Béla Pete |
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| Institution: | a Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, H-1521 Budapest, Hungary
b Department of Physical Chemistry, Technical University of Budapest, H-1521 Budapest, Hungary |
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| Abstract: | Valuable new synthetic intermediates, 4- or 6-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO2 from 2-ethoxycarbonyl-1H-indole-4- or 6-methanesulfonic acids, respectively, which are easily accessible by Fischer-type indolization. |
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| Keywords: | Fischer synthesis 4-(chloromethyl)indoles 6-(chloromethyl)indoles desulfination |
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