Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzed resolution of 3-hydroxy-3-(2-thienyl) propanenitrile |
| |
| Authors: | Ahmed Kamal G.B.Ramesh KhannaR Ramu T Krishnaji |
| |
| Affiliation: | Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
| Abstract: | ![]()
An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2-thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
