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A general protocol for the regio high yielding opening of different glycidol derivatives |
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| Authors: | Carlo Bonini,Lucia ChiummientoMaria Teresa Lopardo,Maddalena PullezFranç oise Colobert,Guy Solladié |
| Affiliation: | a Dipartimento di Chimica, Università della Basilicata, Via N. Sauro, 85, 85100 Potenza, Italy b Laboratoire de stéréochimie associé au CNRS, Université Louis Pasteur, ECPM, 25 rue Becquerel, 67087 Strasbourg cedex 2, France |
| Abstract: | Differently protected glycidol derivatives (with Bn, TBDPS, TBS and MPM groups) have been tested for regioselective ring opening with vinylmagnesium bromide in order to obtain useful five-carbon functionalised homoallylic alcohols. Careful choice of the reagents and experimental conditions allowed a general access to important chiral synthons for asymmetric synthesis. |
| Keywords: | glycidol vinylmagnesium bromide cuprate ring opening |
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