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Solid state and solution conformation of 2-pyridinecarboxylic acid hydrazides: a new structural motif for foldamers |
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| Authors: | Joachim GarricJean-Michel Léger Axelle GrelardMasakazu Ohkita Ivan Huc |
| Institution: | a Institut Européen de Chimie et Biologie, 16 av. Pey Berland, 33607 Pessac Cedex, France b Laboratoire de Pharmacochimie, Université Victor Segalen Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux, France c Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan |
| Abstract: | X-Ray crystallography and NMR show a strong preference for trans conformers of N′-phenyl or N′-(2-pyridyl) 2-pyridinecarboxylic acid hydrazides, stabilized by an NHNpyr. intramolecular hydrogen bond both in the solid state and in solution. This allows us to extrapolate that oligomers of this unit should adopt extended linear conformations. |
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