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An entry to new isoxazoline analogues of dideoxynucleosides by bromonitrile oxide 1,3-dipolar cycloaddition |
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| Authors: | Evdoxia Coutouli-Argyropoulou Paraskevi Pilanidou |
| Affiliation: | Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece |
| Abstract: | A short and efficient synthesis of new isoxazolinyl nucleosides bearing the nucleobase at the 3-position is reported. The synthetic approach relies upon the 1,3-dipolar cycloaddition of bromonitrile oxide to allyl benzoate and subsequent substitution of the bromine by the nucleobase. |
| Keywords: | bromonitrile oxide dipolar cycloaddition isoxazolines dideoxynucleoside analogues |
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