4-Amino-1-oxyl-2,2,6,6-tetramethylpiperidine-3-carboxylic acid (β-TOAC), the first spin-labelled, cyclic, chiral β-amino acid resolved in an enantiomerically pure state期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

4-Amino-1-oxyl-2,2,6,6-tetramethylpiperidine-3-carboxylic acid (β-TOAC), the first spin-labelled, cyclic, chiral β-amino acid resolved in an enantiomerically pure state

Authors:	Karen Wright,Marco CrismaClaudio Toniolo,Roland Tö rö kAntal Pé ter,Michel WakselmanJean-Paul Mazaleyrat

Affiliation:	^a SIRCOB, UMR CNRS 8086, Bât. Lavoisier, University of Versailles, F-78000 Versailles, France ^b Institute of Biomolecular Chemistry, CNR, Department of Organic Chemistry, University of Padova, I-35131 Padova, Italy ^c Department of Inorganic and Analytical Chemistry, University of Szeged, PO Box 440, H-6701 Szeged, Hungary

Abstract:	Amination of 3-carboxymethyl-1-oxyl-2,2,6,6-tetramethyl-4-piperidone with (R)-α-methylbenzylamine, NaBH₃CN reduction of the resulting enamine and removal of the chiral auxiliary from the separated diastereoisomers, led to enantiomerically pure (3S,4S) and (3R,4R) methyl 4-amino-1-oxyl-2,2,6,6-tetramethylpiperidine-3-carboxylates.

Keywords:	chiral nitroxides modified β-amino acids spin-labelled amino acids
本文献已被 ScienceDirect 等数据库收录！