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A new analytical method for anchoring quantification of amines on resin support |
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| Authors: | Alfredo Paio Sylvie GehanneElena Grandini Gianna ReginatoPierfausto Seneci |
| Affiliation: | a GlaxoSmithKline Medicine Research Centre, Via A. Fleming 4, 37135 Verona, Italy b CNR, Via G. Capponi 9, 50121 Firenze, Italy c Nucleotide Analog Pharma AG, Landsberger Strasse 50, 80339 Munchen, Germany |
| Abstract: | A rapid and quantitative method for monitoring the efficiency of coupling of amino compounds to polystyrene resin through a carbamate linker has been developed. para-Nitrophenyl carbonate activating group has been shown to release a valuable chromophore for quantitatively monitoring the progress and the yield of the reaction. |
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