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Oligomeric guanidine synthesis assisted by TFA-sensitive arylsulfonylthiourea |
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| Authors: | Zhongsheng Zhang Tyan CarterErkang Fan |
| Institution: | a Biomolecular Structure Center, Department of Biochemistry, Box 357742, University of Washington, Seattle, WA 98195, USA b Biomolecular Structure Center, Department of Biological Structure, Box 357742, University of Washington, Seattle, WA 98195, USA c Biomolecular Structure Center, Department of Chemistry, Box 357742, University of Washington, Seattle, WA 98195, USA |
| Abstract: | Through arylsulfonyl activation of thiourea, efficient synthesis of oligomeric guanidines can be achieved in either solution or solid-phase. Incorporation of TFA-sensitive arylsulfonyl groups, such as Pbf, during the synthesis greatly simplifies deprotection procedures for obtaining the final oligomeric guanidine products. |
| Keywords: | oligomeric guanidine multivalent ligand peptido-mimetics |
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