A new bicyclic proline-mimetic amino acid |
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| Authors: | Andrea TrabocchiNicoletta Cini Gloria MenchiAntonio Guarna |
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| Affiliation: | Dipartimento di Chimica Organica ‘Ugo Schiff’, Università degli Studi di Firenze, and Istituto di Chimica dei Composti Organometallici-CNR, Polo Scientifico di Sesto Fiorentino, Via della Lastruccia 13, Sesto Fiorentino, I-50019 Firenze, Italy |
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| Abstract: | A new constrained bicyclic α-amino acid proline-mimetic was developed. The synthesis was achieved starting from derivatives of the chiral pool, thus allowing to prepare analogues of either l- or d-proline by choosing appropriate stereoisomers of serine and α,β-isopropylidene-glycerol derivatives. The scaffolds were prepared as N-Fmoc-amino acid suitable for solid-phase peptide synthesis. |
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