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Myrmekiosides a and b, novel mono-o-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of myrmekioderma sp |
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| Authors: | Shunji Aoki Kouichi Higuchi Ai Kato Nobutoshi Murakami Motomasa Kobayashi |
| Affiliation: | Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan |
| Abstract: | Novel mono-O-alkyl-diglycosylglycerols named myrmekiosides A (1) and B (2) were isolated from a marine sponge of Myrmekioderma sp. and their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence. Myrmekiosides A (1) and B (2) reversed the phenotype of melanoma H-ras transformed NIH3T3 cells at 5 μg/ml. |
| Keywords: | Glyceroglycolipid ras Transformed cell Marine metabolite Marine sponge |
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