Radiolysis study of genistein in methanolic solution |
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| Institution: | 1. Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil;2. Centro de Pesquisa Gonçalo Moniz/Fundação Oswaldo Cruz, Salvador, Bahia, Brazil;3. Escola Baiana de Medicina e Saúde Pública/Fundação Bahiana para Desenvolvimento das Ciências, Salvador, Bahia, Brazil;4. Trust-Africa Centre for Health and Population Studies and Southern African Treatment Research Network, South Africa;5. Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista, Bahia, Brazil |
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| Abstract: | The aim of the present work was to identify products obtained from genistein by ionizing radiation and to enhance the antioxidant properties of genistein through radiation-induced transformation. Genistein dissolved in methanol was irradiated γ-rays at a dose of 100 kGy. NMR and (HR) EI-MS spectroscopy were used to identify radiolysis products (GM1 and GM2). We proposed that  CH2OH may be implicated in the formation GM1 and GM2 during radiolysis of genistein in methanol. The genistein in methanol solution showed higher DPPH radical scavenging activity after γ-irradiation. Then, the antioxidant activities of radiolysis products were evaluated and compared to those of genistein. |
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