Crystal structures of atisine 15-acetoxyazomethine and 15-hydroxyazomethine and their biological activities |
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| Authors: | B T Salimov B Tashkhodzhaev M Sh Kodirova F M Tursunkhodzhaeva F N Dzhakhangirov |
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| Institution: | (1) S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences, Republic of Uzbekistan, Tashkent; |
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| Abstract: | The 15-acetoxyazomethine derivative of atisine was prepared from atisine base. Its structure was confirmed by converting it
to atisine 15-hydroxyazomethine and proved by an XSA. Atisine 15-acetoxyazomethine exhibited antiarrhythmic activity in rat
cardiac arrhythmia models induced by CaCl2 and aconitine. Atisine 15-acetoxyazomethine, in contrast with atisine 15-hydroxyazomethine, exhibited local anesthetic activity. |
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