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A Synthesis of Thalidomide |
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| Authors: | Meng‐Yang Chang Chung‐Ho Chang Shui‐Tein Chen Nein‐Chen Chang |
| Abstract: | A synthesis of racemic thalidomide ( 1 ) was described and the important formal 3+3] cycloaddition strategy was a keystep. The total yield of thalidomide ( 1 ) was 18% in five steps from known 3 . |
| Keywords: | Glutarimides Thalidomide Formal [3+3] cycloaddition reaction Phthaloylation |