| Syntheses and Vasodilatory Activities of New Pyrazolo [ 4,3-d ] pyrimidin-7-ones |
| |
| 引用本文： | ZHAO Yan-fang ZHAI Xin CHEN Jiao-yue GUO Shu-chun GONG Ping. Syntheses and Vasodilatory Activities of New Pyrazolo [ 4,3-d ] pyrimidin-7-ones[J]. 高等学校化学研究, 2006, 22(4): 468-473. DOI: 10.1016/S1005-9040(06)60144-X |
| |
| 作者姓名： | ZHAO Yan-fang ZHAI Xin CHEN Jiao-yue GUO Shu-chun GONG Ping |
| |
| 作者单位： | ZHAO Yan-fang，ZHAI Xin，CHEN Jiao-yue，GUO Shu-chun and GONG Ping~ School of Pharmaceutical Engineering，Shenyang Pharmaceutical University，Shenyang 110016，P.R. China |
| |
| 摘 要： | IntroductionAdenosine 3′,5′-cyclic monophosphate (cAMP)and guanosine 3′,5′-cyclic monophosphate(cGMP) areubiquitous second messengers that mediate biologicalresponses to a variety of extracellular cues, includinghormones, neurotransmitters, chemokines…
|
| 关 键 词： | 吡唑[4 3-d]嘧啶-7-酮 合成 生物活性 结构分析 |
| 文章编号： | 1005-9040（2006）-04-468-06 |
| 收稿时间： | 2005-06-13 |
Syntheses and Vasodilatory Activities of New Pyrazolo [4, 3-d] pyrimidin-7-ones |
| |
| Yan-fang ZHAO, Xin ZHAI, Jiao-yue CHEN, Shu-chun GUO,Ping GONG,. Syntheses and Vasodilatory Activities of New Pyrazolo [4, 3-d] pyrimidin-7-ones[J]. Chemical Research in Chinese University, 2006, 22(4): 468-473. DOI: 10.1016/S1005-9040(06)60144-X |
| |
| Authors: | Yan-fang ZHAO Xin ZHAI Jiao-yue CHEN Shu-chun GUO Ping GONG |
| |
| Affiliation: | aSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China |
| |
| Abstract: | A series of novel pyrazolo[4,3-d]pyrimidin-7-ones was designed and synthesized in order to find new potent phosphodiesterase 5 inhibitors(PDE5). The structures of all the compounds were confirmed by IR, 1H NMR and MS; their in vitro vasodilatory activities were tested on isolated rabbit aortic spiral strips. Among them, compound Ⅹ3 displays a significant vasodilatory activity, which is more potent than verapamil. |
| |
| Keywords: | Pyrazolo[4 3-d]pyrimidin-7-one Synthesis Vasodilatory activity |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
