Oxidative and hydrolytic DNA cleavage by Cu(II) complexes of salicylidene tyrosine schiff base and 1,10 phenanthroline/bipyridine |
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Authors: | Pulimamidi Rabindra ReddyAuthor Vitae Addla ShilpaAuthor Vitae |
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Institution: | Department of Chemistry, Osmania University, Hyderabad 500007, India |
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Abstract: | Ternary Cu(II) complexes Cu(II)(saltyr)(B)] (1,2), (saltyr = salicylidene tyrosine, B = 1,10 phenanthroline (1) or 2,2′ bipyridine (2)) were synthesized and characterized by various techniques. The complexes exhibit square pyramidal (CuN3O2) geometry. CT-DNA binding studies revealed that the complexes show good binding propensity (Kb = 3.47 × 104 M−1 and 3.01 × 104 M−1 for 1 and 2, respectively). The role of these complexes in the oxidative and hydrolytic DNA cleavage was studied. The catalytic ability of 1 and 2 follows the order: 1 > 2. The rate constants for the hydrolysis of phosphodiester bond were determined as 2.80 h−1 and 2.11 h−1 for 1 and 2, respectively. It amounts to (0.58-0.77) × 108 fold rate enhancement compared to non-catalyzed DNA cleavage, which is significant. |
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Keywords: | Tyrosine schiff base complexes DNA binding Oxidative DNA cleavage Hydrolytic DNA cleavage Kinetics |
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