| 强碱性条件下的相转移催化合成美多心安 |
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| 引用本文： | 田建文,张小林,彭雪萍.强碱性条件下的相转移催化合成美多心安[J].南昌大学学报(理科版),2005,29(6):529-532. |
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| 作者姓名： | 田建文 张小林 彭雪萍 |
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| 作者单位： | 南昌大学,基础化学实验中心,江西,南昌,330029;南昌大学,基础化学实验中心,江西,南昌,330029;南昌大学,基础化学实验中心,江西,南昌,330029 |
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| 基金项目： | 江西省教育厅科技攻关项目（Z02292） |
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| 摘 要： | 以对甲氧乙基苯酚和环氧氯丙烷为原料，强碱KOH为催化剂，PEG400（聚乙二醇400）为相转移催化剂，通过醚化反应和胺化反应合成了美多心安。本工艺路线简单，原料易得，反应的整体收率达到50％。研究了不同反应条件对反应的影响。对中间体和目标产物进行了IR、^1HNMR、HPLC定性定量分析。确定了较好的合成反应条件。
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| 关 键 词： | 相转移催化 聚乙二醇400 美多心安 合成 |
| 文章编号： | 1006-0464（2005）06-0529-04 |
| 收稿时间： | 2004-12-27 |
| 修稿时间： | 2004年12月27 |
PHASE TRANSFER CATALYZED SYNTHESIS OF METOPROLOL IN CONDITION OF STRONG ALKALI |
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| TIAN Jian-wen,ZHANG Xiao-lin,PENG Xie-ping.PHASE TRANSFER CATALYZED SYNTHESIS OF METOPROLOL IN CONDITION OF STRONG ALKALI[J].Journal of Nanchang University(Natural Science),2005,29(6):529-532. |
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| Authors: | TIAN Jian-wen ZHANG Xiao-lin PENG Xie-ping |
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| Institution: | Chemistry Experiment Center, Nanchang University, Nanchang 330029, China |
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| Abstract: | This paper has studied strong alkali catalyst KOH and phase transfer catalyst PEG400 in synthesizing Metoprolol by 4-(2-methoxy-ethyl)phenol and epichlorohydrin by etherification reaction and amination reaction.The technics of the synthesis is original,the raw materials were easy to be acquired,the route is easy,The yield of product is 50%.The effects of differents reaction conditions were studied.The composition of intermediate and products were examined by IR and 1HNMR method.The appropriate reaction condition were established. |
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| Keywords: | phase transfer catalysis PEG400 metoprolol synthesis |
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