| 金属离子对过亚硝酸根损伤酪氨酸的影响 |
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| 引用本文： | 张伟,罗云敬,王云海,钟儒刚.金属离子对过亚硝酸根损伤酪氨酸的影响[J].无机化学学报,2006,22(6):1113-1117. |
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| 作者姓名： | 张伟 罗云敬 王云海 钟儒刚 |
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| 作者单位： | 北京工业大学生命科学与生物工程学院,北京,100022 |
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| 基金项目： | 北京市科技新星计划项目;北京市自然科学基金;教育部留学回国人员科研启动基金 |
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| 摘 要： | NO· and ·O2- combine each other to form peroxynitrite (ONOO-) in vivo. Peroxynitrite is very cytotoxic, and it damages many biomolecules. 3-nitrotyrosine and dityrosine are two main products from the reaction of ONOO- and tyrosine. Lots of metallic ions in vivo influence the modification of tyrosine by peroxynitrite. UV-Vis and Fluorescence spectrophotometer were used to study the catalysis and inhibition of metallic ions on the production of 3-nitrotyrosine and dityrosine in vitro. Present results showed that Co(Ⅱ), Cu(Ⅱ) and Mn(Ⅱ) enhance the production of 3-nitrotyrosine, and among them Co(Ⅱ) and Mn(Ⅱ) have been reported rarely before about it. In addition, Mn(Ⅱ) inhibits the production of dityrosine to a certain extent.
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| 关 键 词： | 过亚硝酸根 L-酪氨酸 3-硝基酪氨酸 二聚酪氨酸 金属离子 |
| 文章编号： | 1001-4861(2006)06-1113-05 |
| 收稿时间： | 2006-01-09 |
| 修稿时间： | 2006-03-21 |
Influence of Metallic Ions on Tyrosine Modification by Peroxynitrite |
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| ZHANG Wei,LUO Yun-Jing,WANG Yun-Hai and ZHONG Ru-Gang.Influence of Metallic Ions on Tyrosine Modification by Peroxynitrite[J].Chinese Journal of Inorganic Chemistry,2006,22(6):1113-1117. |
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| Authors: | ZHANG Wei LUO Yun-Jing WANG Yun-Hai and ZHONG Ru-Gang |
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| Institution: | College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022,College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022,College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022 and College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022 |
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| Abstract: | |
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| Keywords: | peroxynitrite L-tyrosine 3-nitrotyrosine dityrosine metallic ions |
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