A simple instrument to characterize convective and diffusive transport of single hollow fibers of short length |
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| Institution: | 1. School of Materials Science and Engineering, Key Laboratory of Advanced Energy Storage Materials of Guangdong Province, South China University of Technology, Guangzhou, 510641, PR China;2. Department of Materials Science, Fudan University, Shanghai, 200433, PR China;3. School of Materials Science and Engineering, Anhui University of Technology, Maanshan, Anhui, 243002, PR China;4. Key Laboratory for Fuel Cell Technology in Guangdong Province, Guangzhou, 510641, PR China;5. China-Australia Joint Laboratory for Energy & Environmental Materials, South China University of Technology, Guangzhou, 510641, PR China;1. Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran;2. National Petrochemical Company, Petrochemical Research and Technology Company, Catalyst Research Group, Iran;1. Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, China;2. School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, China;3. Material and Process Synthesis, College of Science, Engineering and Technology, University of South Africa, Johannesburg, South Africa |
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| Abstract: | The use hollow fiber membranes for cell encapsulation is being developed as an experimental transplantation technology in which a permselective membrane physically isolates grafted cells from directly interacting with host cells or tissue. Although laboratory characterization of commercial ultrafiltration and dialysis membranes using multi-fiber test modules is well established, a simple apparatus for characterizing the transport properties of small individual segments of hollow fiber membrane has not been described. In the current study, we describe an instrument for evaluating the diffusive and convective transport characteristics of individual cell encapsulation membranes at size scales typically used in animal and human clinical studies. The performance capabilities of the instrument are described, as well as methods for determining hydropermeability, diffusive permeability, and solute rejection. |
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