Four-component tandem protocol for the stereoselective synthesis of highly functionalized [1,4]-thiazines |
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| Authors: | Sethuraman Indumathi |
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| Affiliation: | Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India |
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| Abstract: | The one-pot, four-component tandem reaction of ethyl 2-[(2-oxo-2-arylethyl)sulfonyl]acetate/ethyl 2-[(2-ethoxy-2-oxoethyl)sulfonyl]acetate, an aromatic aldehyde and pyrrolidine provides a rapid and facile access to new ethyl 3-aroyl-1-benzyl-2,2-dioxo-4-aryloctahydro-2-pyrrolo[2,1-c][1,4]thiazine-1-carboxylates/diethyl 1-benzyl-2,2-dioxo-4-aryloctahydro-2-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylates. This reaction shows high stereoselectivity and proceeds in good yields. |
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| Keywords: | Pyrrolothiazine Pyrrolidine Stereoselectivity Tandem |
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