Synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction using organocatalysts |
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Authors: | Atul Kumar Ram Awatar Maurya |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP 226001, India |
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Abstract: | A novel and green approach for efficient and rapid synthesis of polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using organocatalysts at room temperature was reported. The process is a simple, environmentally friendly, rapid, and high yielding reaction for the synthesis of polyhydroquinoline derivatives. The catalytic efficiency of various small organocatalysts such as l-proline, trans-4-hydroxy-l-proline, l-thiaproline, dl-phenylglycine, and (−)-cinchonidine was studied under aqueous, organic, and solvent free conditions. |
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Keywords: | Hantzsch reaction Polyhydroquinoline derivatives Green synthesis Organocatalyst Multicomponent reaction |
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