Early detection of insulin fibrillation: a fluorescence lifetime assay to probe the pre-fibrillar regime |
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| Authors: | Mohanty Jyotirmayee Choudhury Sharmistha Dutta Pal Haridas Bhasikuttan Achikanath C |
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| Affiliation: | Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India. jyotim@barc.gov.in |
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| Abstract: | ![]()
Using human insulin, we report for the first time, the evaluation of fluorescence lifetime of an extrinsically added fluorogenic dye, Thioflavin T (ThT), as a more sensitive and convenient method for the assessment of fibrillation in the pre-fibrillar regime. |
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