Synthèse d'analogues furannique et nitro-2 furannique du benzo[e]pyrène

Pyreno4,5-b]furan, a heterocyclic analogue of benzoe]pyrene, and its 10-nitro derivative were prepared in six steps staring from 5-formyl-4-hydroxypyrene. These isomers of the previously described pyreno1,2-b]-furan, pyreno2,1-b]furan, 10-nitopyreno1,2-b]furan and 10-nitropyreno-2,1-b]furan are of particular interest due to their mutagenic activities.