Reactions of vinylidenediphosphonic acid with nucleophiles. 4. Addition of amino acids,diastereotopy of phosphorus atoms in the addition products

Previously unknown carboxy-substituted 2-alkylaminoethylidene-1,1-diphosphonic acids were synthesized by the reaction of vinylidenediphosphonic acid with amino acids. The reaction products, containing chiral centers, show nonequivalence of the phosphorus atoms in the³¹P NMR spectra as a result of diestereotopy.Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 9, pp. 2180–2183, September, 1992.