| 磷酰化肽链中电子转移的ESR研究 |
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| 引用本文： | 汪志勇,张志成,张曼维,姚思德,屠铁成,林念芸,张其锦.磷酰化肽链中电子转移的ESR研究[J].物理化学学报,1995,11(4):375-380. |
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| 作者姓名： | 汪志勇 张志成 张曼维 姚思德 屠铁成 林念芸 张其锦 |
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| 作者单位： | Department of Chemical Physics,University of Science and Technology of China,Hefei 230026,Laboratory of Radiation Chemistry,Shanghai Institute of Nuclear Research,Shanghai 201800,Department of Material Science and Engineering,University of Science and Technology of China,Hefei 230026 |
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| 摘 要： | 当前生命科学正以前所未有的速度向前发展，从对核酸的深入研究开始过渡到对蛋白质结构与功能的注意，尤其是近年来基因调控研究的重大进展是发现非组蛋白具有高度的磷酸化的特性［1］，研究证明，核内蛋白磷酸化和去磷酸化则是基因表达调控的重要方式之一［2，3］，它是酶活性调节、基因表达调控、细胞转化恶变的关键环节；同时在解决肿瘤的发生和治疗、病毒的感染和诊治、辐射损伤、抗衰老等实际问题上有突出意义，如1992年Krebus和Fisher因为在蛋白的可逆磷酸化方面的突出贡献而获得诺贝尔生理和医学奖．而电子转移是一切化学变化的基础…
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| 关 键 词： | 磷酰化肽 电子转移 顺磁共振 |
| 收稿时间： | 1994-01-25 |
| 修稿时间： | 1994-07-27 |
Research on Electron Transfer in Phosphorylated Peptide by ESR |
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| Wang Zhiyong, Zhang Zhicheng, Zhang Manwei.Research on Electron Transfer in Phosphorylated Peptide by ESR[J].Acta Physico-Chimica Sinica,1995,11(4):375-380. |
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| Authors: | Wang Zhiyong Zhang Zhicheng Zhang Manwei |
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| Institution: | Department of Chemical Physics,University of Science and Technology of China,Hefei 230026|Laboratory of Radiation Chemistry,Shanghai Institute of Nuclear Research,Shanghai 201800|Department of Material Science and Engineering,University of Science and Technology of China,Hefei 230026 |
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| Abstract: | Electron transfer (ET) is an important elementary step of chemical reaction.Phosphorus is the center of energy expression in biological system. As a result, the research on the ET of phosphoryl and nonphosphoryl peptides is very important for us to understand the role of phosphorus in life and reveal the secrets of life. In this paper, the ET in some phosphoryl and nonphosphoryl peptides are studied by ESR. It is observed that the electron transfers along the backbone of the peptide and that phosphoryl group takes part in the elementary process in the phosphoryl peptide first. |
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| Keywords: | Phosphorylated peptide Electron transfer ESR |
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